| 主权项 |
1. A pharmaceutical composition comprising:
A. an epithelial sodium channel (ENaC) inhibitor; and B. at least one ABC transporter modulator, the ABC transporter modulator comprising: I. a compound of Formula A: or a pharmaceutically acceptable salt thereof, wherein: Ar1 is selected from: wherein ring A1 5-6 membered aromatic monocyclic ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; or A1 and A2, together, is an 8-14 aromatic, bicyclic or tricyclic aryl ring, wherein each ring contains 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; or II a compound of Formula B: or a pharmaceutically acceptable salt thereof wherein: each BR1 is an optionally substituted C1-6 aliphatic, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted C3-10 cycloaliphatic, or an optionally substituted 4 to 10 membered heterocycloaliphatic, carboxy [e.g., hydroxycarbonyl or alkoxycarbonyl], alkoxy, amido [e.g., aminocarbonyl], amino, halo, cyano, alkylsulfanyl, or hydroxy; provided that at least one R1 is an optionally substituted aryl or an optionally substituted heteroaryl and said R1 is attached to the 3- or 4-position of the phenyl ring; each BR2 is hydrogen, an optionally substituted C1-6 aliphatic, an optionally substituted C3-6 cycloaliphatic, an optionally substituted phenyl, or an optionally substituted heteroaryl; each BR4 is an optionally substituted aryl or an optionally substituted heteroaryl; each n is 1, 2, 3, 4 or 5; and ring A is an optionally substituted cycloaliphatic or an optionally substituted heterocycloaliphatic where the atoms of ring A adjacent to C* are carbon atoms, and each of which is optionally substituted with 1, 2, or 3 substituents; or III a compound of Formula C: or a pharmaceutically acceptable salt thereof, wherein each CR1 is a an optionally substituted C1-C6 aliphatic, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted 3 to 10 membered cycloaliphatic, an optionally substituted 3 to 10 membered heterocycloaliphatic, carboxy [e.g., hydroxycarbonyl or alkoxycarbonyl], amido, amino, halo, or hydroxy, provided that at least one R1 is an optionally substituted aryl or an optionally substituted heteroaryl attached to the 5- or 6-position of the pyridyl ring, each R2 is hydrogen, an optionally substituted C1-6 aliphatic, an optionally substituted C3-6 cycloaliphatic, an optionally substituted phenyl, or an optionally substituted heteroaryl, each CR3 and CR′3 together with the carbon atom to which they are attached form an optionally substituted C3-7 cycloaliphatic or an optionally substituted heterocycloaliphatic, each CR4 is an optionally substituted aryl or an optionally substituted heteroaryl, each n is 1-4; or IV. a compound of Formula D: or a pharmaceutically acceptable salt thereof, wherein R1 is —ZADR4, and wherein each ZA is independently a bond or an optionally substituted branched or straight C1-6 aliphatic chain wherein up to two carbon units of ZA are optionally and independently replaced by —CO—, —CS—, —CONDRA—, —CONDRANDRA—, —CO2—, —OCO—, —NDRACO2—, —O—, —NDRACONDRA—, —OCONDRA—, —NDRANDRA—, —NDRACO—, —S—, —SO—, —SO2—, —NDRA—, —SO2NDRA—, —NDRASO2—, or —NDRASO2NDRA—, Each DR4 is independently DRA, halo, —OH, —NH2, —NO2, —CN, or —OCF3, each DRA is independently hydrogen, an optionally substituted aliphatic, an optionally substituted cycloaliphatic, an optionally substituted heterocycloaliphatic, an optionally substituted aryl, or an optionally substituted heteroaryl, DR2 is —ZBDR5, and wherein each ZB is independently a bond or an optionally substituted branched or straight C1-6 aliphatic chain wherein up to two carbon units of ZB are optionally and independently replaced by —CO—, —CS—, —CONDRB—, —CONDRBNDRB—, —CO2—, —OCO—, —NDRBCO2—, —O—, —NDRBCONDRB—, —OCONDRB—, —NDRBNDRB—, —NDRBCO—, —S—, —SO—, —SO2—, —NDRB—, —SO2NDRB—, —NDRBSO2—, or —NDRBSO2NDRB—, each DR5 is independently DRB, halo, —OH, —NH2, —NO2, —CN, —CF3, or —OCF3, Each DRB is independently hydrogen, an optionally substituted aliphatic, an optionally substituted cycloaliphatic, an optionally substituted heterocycloaliphatic, an optionally substituted aryl, or an optionally substituted heteroary, and wherein any two adjacent R2 groups together with the atoms to which they are attached form an optionally substituted carbocycle or an optionally substituted heterocycle, wherein ring A is an optionally substituted 3-7 membered monocyclic ring having 0-3 heteroatoms selected from N, O, and S and ring B is a group having formula Ia. |
