ANTI-JAGGED ANTIBODIES AND METHODS OF USE

摘要

The disclosure provides anti-Jagged antibodies and methods of using the same.

主权项

1. An isolated antibody that binds to Jagged1, the antibody comprising at least one, two, three, four, five, or six HVRs selected from:
(a) HVR-H1 comprising the amino acid sequence of SEQ ID NO:81; (b) HVR-H2 comprising an amino acid sequence of SEQ ID NO:84; (c) HVR-H3 comprising an amino acid sequence of SEQ ID NO:87; (d) HVR-L1 comprising the amino acid sequence of SEQ ID NO:110; (e) HVR-L2 comprising the amino acid sequence of SEQ ID NO:111; and (f) HVR-L3 comprising an amino acid sequence of SEQ ID NO:114.