| 发明名称 |
NOVEL CRYSTALLINE FORMS OF 4,4'-[4-FLUORO-7({4-[4-(3-FLUORO-2-METHYLPHENYL)BUTOXY]PHENYL} ETHYNYL)-2-METHYL-1H-INDOLE-1,3-DIIYL]DIBUTANOIC ACID, 4,4'-[2-METHYL-7-({4-[4-(PENTAFLUOROPHENYL)BUTOXY]PHENYL} ETHYNYL)-1H-INDOLE-1,3-DIIYL]DIBUTANOIC ACID AND 4,4'-[4-FLUORO-2-METHYL-7-({4-[4-(2,3,4,6-TETRAFLUOROPHENYL) BUTOXY]PHENYL} ETHYNYL)-1H-INDOLE-1,3-DIIYL]DIBUTANOIC ACID |
| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to novel crystalline forms of 4,4'-[4-fluoro-7-({4-[4-(3-fluoro-2-methylphenyl)butoxy]phenyl}ethynyl)-2-methyl-1H-indole-1,3-diiyl]dibutanoic acid, 4,4'-[2-methyl-7-({4-[4-(pentafluorophenyl)butoxy]phenyl}ethynyl)-1H-indole-1,3-diiyl]dibutanoic acid and 4,4'-[4-fluoro-2-methyl-7-({4-[4-(2,3,4,6-tetrafluorophenyl)butoxy]phenyl}ethynyl)-1H-indole-1,3-diiyl]dibutanoic acid.EFFECT: obtaining novel compounds.18 cl, 16 dwg, 7 tbl, 24 ex |
| 申请公布号 |
RU2560147(C2) |
申请公布日期 |
2015.08.20 |
| 申请号 |
RU20130102490 |
申请日期 |
2011.06.20 |
| 申请人 |
ONO FARMAS'JUTIKAL KO., LTD. |
发明人 |
TAKEHUTI DZJUN;ITADANI SATOSI;UEHDA DZJUNJA;ONO SIDZUKA;NEHKADO TAKAKHIRO;FUDZITA MANABU |
| 分类号 |
C07D209/18;A61K31/405;A61P11/06;A61P37/08;A61P43/00 |
主分类号 |
C07D209/18 |
| 代理机构 |
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