Oral pharmaceutical dosage forms

摘要

Abuse-resistant oral dosage forms suitable for administration of pharmacologically active agents are provided. Process Scheme 4 Process Scheme 5 Sucrose acetate isobutyrate Op 40 Sucrose acetate isobutyrate Triacetin - Triacetin Cellulose acetate butyrate 44 Butylated hydroxytoluene/ Butylated hydroxytoluene/ 10%v isopropyl myristate I O%v isopropyl myristate (premixed) (premixed) Compounding 4- 90%v isopropyl myristate Oxycodone base (micronized) 10 4 Silicon dioxide Hydroxyethyl cellulose -4- Cellulose acetate butyrate Silicon dioxide - 0 - Oxycodone base (micronized) 90%v isopropyl myristate 10 Hydroxyethyl cellulose Encapsulation Capsules to packaging Capsule Sealing Capsules to packaging Fig. 2