发明名称 METHODS FOR TREATING AND DIAGNOSING BLINDING EYE DISEASES
摘要 This invention relates to, in part, methods and compositions that are useful for the diagnosis, treatment, or prevention of a blinding eye disease, including in the discovery of drugs that are efficacious against these diseases. Diseases include, for example, age related macular degeneration and reticular pseudodrusen disease, and the methods described herein include, for example, the method named delayed near infrared analysis (DNIRA).
申请公布号 US2015231277(A1) 申请公布日期 2015.08.20
申请号 US201514636639 申请日期 2015.03.03
申请人 Translatum Medicus Inc. 发明人 Boyd Shelley Romayne
分类号 A61K49/00;A61K9/00 主分类号 A61K49/00
代理机构 代理人
主权项 1. A method for identifying whether a candidate compound is useful for the treatment of a blinding eye disease, comprising: (a) administering an effective amount of a test compound to an animal whose eye comprises: (i) a fluorescent compound in an amount effective to indicate the presence of a blinding eye disease in the animal and(ii) a toxin in an amount effective to induce atrophy of ocular tissue; (b) exposing the eye to light having a wavelength and intensity effective to cause the fluorescent compound to fluoresce; (c) comparing the eye's fluorescence pattern to a fluorescence pattern of an animal's eye that comprises the fluorescent compound and the toxin, but not the test compound; and (d) selecting the test compound as a candidate compound if the result of the comparison of step (c) indicates that the test compound is useful for the treatment of a blinding eye disease.
地址 Toronto CA