NOVEL CRYSTALLINE FORM OF BORTEZOMIB AND PREPARATION METHOD THEREOF

摘要

The present invention relates to a novel crystalline form of bortezomib and a preparation method thereof. The novel crystalline form of bortezomib is prepared by crystallizing bortezomib from a mixed solvent of methanol and acetonitrile and filtering the formed crystal. The novel crystalline form of bortezomib according to the present invention has substantially improved stability compared to known crystalline forms.