| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: group of inventions relates to medicine and deals with liquid pharmaceutical composition for treating disorder in which TNF-alpha activity is harmful, with said composition having pH from approximately 5.0 to 6.4 and including approximately 35-55 mg/ml of polyol and approximately 40-200 mg/ml of human antibody against TNF-alpha, where composition does not contain NaCl filler. Group of inventions also deals with method of treating disorder, associated with harmful activity of TNF-alpha, in subject, which includes introduction of said composition to subject.EFFECT: group of inventions provides preparations with high concentration of antibody, possessing prolonged stability and characteristics useful for subcutaneous introduction.49 cl, 11 ex, 26 dwg, 27 tbl |
