发明名称 |
NITROGEN-CONTAINING AROMATIC HETEROCYCLIC COMPOUND |
摘要 |
Provided is a compound useful as a prophylactic and/or therapeutic agent for bladder cancer. As a result of studies on compounds having FGFR inhibitory action, the present inventors have found that the nitrogen-containing aromatic heterocyclic compounds of the present invention have inhibitory action on FGFR1, FGFR2, and/or FGFR3, particularly, mutant FGFR3, and thus, the present invention has been accomplished. The nitrogen-containing aromatic heterocyclic compound of the present invention can be used as a therapeutic agent for various cancers related to FGFR1, FGFR2, and/or FGFR3, such as lung cancer and hormone therapy-resistant breast cancer, stomach cancer, triple negative breast cancer, endometrial cancer, bladder cancer, and glioblastoma, particularly as a prophylactic and/or therapeutic agent for mutant FGFR3-positive bladder cancer. |
申请公布号 |
EP2821402(A4) |
申请公布日期 |
2015.08.19 |
申请号 |
EP20130754501 |
申请日期 |
2013.02.26 |
申请人 |
ASTELLAS PHARMA INC.;KOTOBUKI PHARMACEUTICAL CO., LTD. |
发明人 |
KAMEDA, MINORU;KURIWAKI, IKUMI;IIKUBO, KAZUHIKO;HISAMICHI, HIROYUKI;KAWAMOTO, YUICHIRO;MORITOMO, HIROYUKI;SUZUKI, TOMOYUKI;FUTAMI, TAKASHI;SUZUKI, ATSUSHI;TSUNOYAMA, KAZUHISA;ASAUMI, MAKOTO;TOMIYAMA, HIROSHI;NODA, ATSUSHI;IWAI, YOSHINORI;TOKUZAKI, KAZUO;OKADA, HARUKI;MIYASAKA, KOZO |
分类号 |
C07D239/42;A61K31/4545;A61K31/506;A61P35/00;A61P43/00;C07D239/47;C07D401/12;C07D401/14;C07D403/12;C07D405/14;C07D413/12;C07D471/10;C07D487/20 |
主分类号 |
C07D239/42 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|