Griseofulvin analogues for the treatment of cancer by inhibition of centrosomal clustering

摘要

The invention relates to compounds of the formula (I), where the symbols have the meaning given in the specification, for use in a method for treating cancer, to use of these compounds for the manufacture of a pharmaceutical composition for the treatment of cancer, and to methods of treatment for said diseases employing a compound of formula (I).;

主权项

1. A compound of the formula (I) wherein the symbols in formula (I) have the following meanings: A is ═O, X is Cl, Y is —O—, Z is —(CH2)n—, n is 0 or 1, R2 is hydrogen or halogen, R1 is, in case R2 is hydrogen and n is other than 0: phenyl or pyridyl, wherein the phenyl, or pyridyl group is substituted on one or more ring carbon atoms by identical or different substituents R10, R1 is, in case R2 is hydrogen and n is 0: phenyl, wherein the phenyl group is substituted on one or more ring carbon atoms by identical or different substituents R10, R1 is, in case R2 is halogen: linear or branched (C1-C10)-alkyl, R10 is halogen, nitro, linear or branched (C1-C10)-alkyl, phenyl hydroxyl-(C1-C4)-alkyl, or halogen-(C1-C4)-alkyl, R3 is methyl, R4 is methyl,and/or a pharmaceutically acceptable salt thereof.