| 主权项 |
1. A cationic amphipathic compound of formula (I): in which:
R corresponds to formula (II): in which:
R1 and R2, identical or different, represent a linear, branched and/or cyclic, saturated or unsaturated hydrocarbon group comprising from 6 to 24 carbon atoms;A and B, identical, represent-O—C(O)—; —CO—NH—; —NH—CO—; —NH— or —O— group; orA and B, different, represent a —C(O)—O—; —O—C(O)—; —CO—NH—; —NH—CO—; —NH— or —O— group;a is an integer comprised between 1 and 6;b is an integer comprised between 0 and 6; andD represents an —NH—, —CO—, —O— or —S— group; E represents a linear or branched hydrocarbon group which can comprise from 1 to 15 carbon atoms, and which can optionally comprise one or more heteroatoms; m is 1; AA represents an amino acid radical; n is an integer equal to 0 or 1; W1 and W2, identical or different, represent a linear or branched hydrocarbon group which can comprise from 1 to 15 carbon atoms, which can optionally comprise one or more heteroatoms; L represents an ester (CO—O—), disulfide (—S—S—), vinyl ether (—O—C═C—), acylhydrazone (CO—NR—N═CR′R″) group; p is an integer equal to 0 or 1; Y is a branched hydrocarbon group which can comprise from 1 to 20 carbon atoms, and/or one or more heteroatoms, and which can optionally be covalently coupled with the W2 or AA or E or R group on the one hand, and to at least two Y and/or Z groups on the other hand; q is an integer comprised between 0 and 8; Z represents a basic amino acid; r is an integer comprised between 1 and 16, it being understood that if q is equal to 1 then r is at least equal to 2 and that if r is greater than 1, then the Z groups can be identical or different; and s is an integer equal to 1 or 2;and physiologically acceptable addition salts thereof. |
