| 发明名称 |
Oligomer-protease inhibitor conjugates |
| 摘要 |
The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the small molecule drug not attached to the water-soluble oligomer. |
| 申请公布号 |
US9107956(B2) |
申请公布日期 |
2015.08.18 |
| 申请号 |
US201314055581 |
申请日期 |
2013.10.16 |
| 申请人 |
NEKTAR THERAPEUTICS |
发明人 |
Riggs-Sauthier Jennifer;Cheng Lin;Viegas Tacey X.;Gu Xuyuan;Duarte Franco J.;Zhang Wen |
| 分类号 |
A61K47/48 |
主分类号 |
A61K47/48 |
| 代理机构 |
|
代理人 |
Wilson Mark A. |
| 主权项 |
1. A compound of the following Formulawherein:
X is a stable amide linkage; POLY is a poly(alkylene oxide) of between 1 and 30 monomers; and R1 is benzyloxycarbonyl or 2-quinolylcarbonyl. |
| 地址 |
San Francisco CA US |
