发明名称 |
Methods for treating neural cell swelling |
摘要 |
A composition comprising a novel Ca2+-activated, [ATP]i-sensitive nonspecific cation (NCCa-ATP) channel is described. The channel is found in mammalian neural cells and exhibits a different sensitivity to block by various adenine nucleotides, and is activated by submicromolar [Ca]i. The NCCa-ATP channel is activated under conditions of ATP depletion, which causes severe cell depolarization, followed by cell swelling. The NCCa-ATP channel is regulated by a sulfonylurea receptor and is inhibited by sulfonylurea compounds glibenclamide and tolbutamide. Methods employing compositions comprising the NCCa-ATP channel to screen for compounds that block the channel and the use of such antagonists as therapeutics in preventing brain swelling and damage are described. In addition, methods employing compositions comprising the Kir2.3 channel to screen for compounds that open the channel and the use of such antagonists as therapeutics in preventing brain swelling and damage are described. |
申请公布号 |
US9107932(B2) |
申请公布日期 |
2015.08.18 |
申请号 |
US201414184947 |
申请日期 |
2014.02.20 |
申请人 |
University of Maryland, Baltimore;The United States of America as Represented by the Department of Veterans Affairs |
发明人 |
Simard J. Marc;Chen Mingkui |
分类号 |
A61K31/18;A61K31/64;A61K31/435;A61K31/198;A61K31/7076;A61K31/00;A61K31/175;A61K31/426;A61K31/4439;B01J19/00;B32B37/12;C07K14/705;G01N33/68;A61K31/195;A61K31/197;A61K31/4015;A61K31/403;A61K31/4453;B29L31/00 |
主分类号 |
A61K31/18 |
代理机构 |
Norton Rose Fulbright US LLP |
代理人 |
Norton Rose Fulbright US LLP |
主权项 |
1. A method of treating a subject having brain injury or cerebral ischemia, comprising the step of administering an antagonist of a NCca-ATP channel that blocks the channel, prevents the channel opening, and/or reduces the magnitude of membrane current through the channel, wherein the antagonist is a sulfonylurea compound or a benzamido derivative. |
地址 |
Baltimore MD US |