Corynebacteria having enhanced L-lysine productivity and a method of producing L-lysine using the same

摘要

A variant of Corynebacterium shows activity greater than the endogenous activity of aspartate aminotransferase, aspartate kinase, aspartate semialdehyde dehydrogenase, dihydrodipicolinate synthase, dihydropicolinate reductase and diaminopimelate dicarboxylase and additionally pyruvate carboxylase. The variant is used in a method of producing L-lysine.

主权项

1. A modified Corynebacteria microorganism, in which the following genes are overexpressed compared to respective endogenous expression thereof, wherein the genes are involved in lysine production, and wherein the overexpressed genes in the microorganism consist essentially of:
a gene encoding aspartate aminotransferase; a gene encoding aspartate kinase; a gene encoding aspartate semialdehyde dehydrogenase; a gene encoding dihydrodipicolinate synthase; a gene encoding dihydropicolinate reductase; and a gene encoding diaminopimelate decarboxylase.