| 摘要 |
The presently disclosed subject matter provides nitric oxide-releasing polysaccharides and oligosaccharides, in particular, polyglucosamines, and their use in biomedical and pharmaceutical applications. More particularly, in some embodiments, the presently disclosed subject matter provides nitric oxide-releasing polysaccharides and oligosaccharides that release nitric oxide in a controlled and targeted manner, thereby prolonging the therapeutic effects of nitric oxide and improving the specificity of nitric oxide delivery to targeted cells and/or tissues. |
| 主权项 |
1. A polyglucosamine comprising,
at least one structural unit: and optionally, at least one structural unit: wherein,
R1, R2, R3 and R4, if present, are each independently selected from the group consisting of hydrogen, C1-5 alkyl(C═O)— and C1-5 alkyl; in each instance, is a single or double bond,wherein in each instance where it is a double bond, R1, R2, R3 or R4 attached to the double bond-O is absent; when R1 is absent, R5 is hydrogen, hydroxyl, C1-5 alkyl or C1-5 alkoxy; when R3 is absent, R6 is hydrogen, hydroxyl, C1-5 alkyl or C1-5 alkoxy;wherein in each instance where it is a single bond, R1, R2, R3 or R4 attached to the double bond-O is present; when R1 is present, R5 is hydrogen; when R3 is present, R is hydrogen;Q is —(CRcRd)v—;
wherein Rc and Rd are independently hydrogen or C1-5 alkyl; and v is an integer from 2 to 6;p is an integer from 1 to 10;A iswherein, L is S, O or N; and
G, in each instance, is independently, hydrogen, or is taken together with L to form a nitric oxide donor or is absent;
X is hydrogen, C1-5 alkyl or is taken together with N to form a nitric oxide donor;B is one hydrogen or —Y—Z, wherein Y is a spacer and Z is a polymer or a terminus;D is —NRaRb, wherein Ra and Rb are independently selected from the group consisting of hydrogen, formyl, C1-5 alkyl(C═O)—, C1-5 alkyl and C1-5 alkyl ester;or D is |
