发明名称 |
ANTIBODY AGAINST MUCIN 4 (MUC 4) GLYCOPEPTIDE AND USE THEREFOR |
摘要 |
The present invention provides: an antibody that has specificity for MUC 4 having a sugar chain structure that is expressed at a high level in cancer cells; a glycopeptide that constitutes an antigen that is suitable for producing this antibody; and a new means and method for the diagnosis, prevention, and/or treatment of cancer by means of the aforementioned antibody. The present invention relates to a monoclonal antibody against a glycopeptide. The glycopeptide comprises a human MUC 4 tandem unit peptide having an amino acid sequence represented by SEQ ID NO: 1, and an O-linked sugar chain. The O-linked sugar chain is N-acetylgalactosamine (GalNAc) and binds to threonine, which is the 8th amino acid of the tandem unit peptide. The present invention further includes: a glycopeptide for use in the production of a monoclonal antibody against human MUC 4; a method for detecting MUC 4 in a human body fluid sample; a kit that includes the abovementioned monoclonal antibody; and a pharmaceutical composition for the prevention and/or treatment of malignant tumors that contains the abovementioned monoclonal antibody as an active component. |
申请公布号 |
WO2015119180(A1) |
申请公布日期 |
2015.08.13 |
申请号 |
WO2015JP53175 |
申请日期 |
2015.02.05 |
申请人 |
MEDICINAL CHEMISTRY PHARMACEUTICALS, CO., LTD. |
发明人 |
NISHIMURA SHINICHIRO;MIYOSHI RISHO;NARUCHI KENTARO;TANAKA MASAKAZU |
分类号 |
C07K16/18;A61K39/395;A61P35/00;C07K9/00;C07K14/47;C12P21/08;G01N33/53;G01N33/574 |
主分类号 |
C07K16/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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