发明名称 |
Insulin secretion peptide derivative in which charge on N-terminus is modified |
摘要 |
The present invention relates to an insulin secretion peptide derivative in which the charge on the N-terminus is modified and a pharmaceutical composition comprising the same, specifically, is characterized in that, in the insulin secretion peptide derivative, the positive charge on the N-terminus of an insulin secretion peptide is changed to a neutral charge or net negative charge in a neutral pH. The insulin secretion peptide derivative according to the present invention exhibits higher insulin secretion ability and blood glucose-reducing ability than natural insulin secretion peptides while maintaining the stability in the bloodstream because dissociation from a GLP-1 receptor rapidly progresses due to the change in the charge on the N-terminus, and thus is very useful in treating Type 2 diabetes. |
申请公布号 |
AU2014204193(A1) |
申请公布日期 |
2015.08.13 |
申请号 |
AU20140204193 |
申请日期 |
2014.01.03 |
申请人 |
HANMI PHARM. CO., LTD. |
发明人 |
JUNG, SUNG YOUB;HWANG, SANG YOUN;CHOI, IN YOUNG;PARK, SUNG HEE;KWON, SE CHANG |
分类号 |
C07K14/575;A61P3/10 |
主分类号 |
C07K14/575 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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