发明名称 |
INHIBITION OF NEAT1 FOR TREATMENT OF SOLID TUMORS |
摘要 |
The present application relates to the field of cancer, particularly the field of solid tumors. It was found that a particular long non-coding RNA (lncRNA), NEAT1, an essential architectural component of nuclear paraspeckles, is required for the survival of cancer, but not that of normal, non-transformed, cells. Inhibition of NEAT1 reduces cell viability of cancer cells and induces apoptosis. These data identify NEAT1 as a novel therapeutic target for treatment of solid tumors. |
申请公布号 |
CA2937058(A1) |
申请公布日期 |
2015.08.13 |
申请号 |
CA20152937058 |
申请日期 |
2015.02.09 |
申请人 |
VIB VZW;KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D |
发明人 |
MARINE, JEAN-CHRISTOPHE;STANDAERT, LAURA |
分类号 |
C12N15/113;A61K31/7088;A61P35/00 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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