| 发明名称 |
ANTI-CD40 ANTIBODIES |
| 摘要 |
PROBLEM TO BE SOLVED: To provide an anti-CD40 humanized antibody for the diagnostic and therapeutic use of CD40 which is a 48 kDa type I integral membrane glycoprotein and a member of a tumor necrosis factor (TNF) receptor super-family.SOLUTION: An anti-CD40 humanized antibody specifically binds to human CD40 having an antagonistic activity IC50 of less than 1 nM, and has no agonism up to 100 μg/ml in B cell proliferation, wherein the antibody is further characterized in that the antibody has an in vivo half-life in non-human primates that is at least 10 days. |
| 申请公布号 |
JP2015145383(A) |
申请公布日期 |
2015.08.13 |
| 申请号 |
JP20150049311 |
申请日期 |
2015.03.12 |
| 申请人 |
BOEHRINGER INGELHEIM INTERNATL GMBH |
发明人 |
RACHEL BARRETT;SCOTT BRODEUR;KEITH A CANADA;TOBIAS LITZENBURGER;SINGH SANJAYA |
| 分类号 |
C07K16/46;A61K39/395;A61K45/00;A61P1/04;A61P1/16;A61P3/10;A61P5/00;A61P7/00;A61P7/04;A61P7/06;A61P9/00;A61P13/12;A61P15/00;A61P17/00;A61P17/06;A61P21/00;A61P21/04;A61P25/00;A61P29/00;A61P37/06;A61P43/00;C07K16/28;C12N15/02 |
主分类号 |
C07K16/46 |
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