发明名称 |
ENHANCED DELIVERY OF IMMUNOSUPPRESSIVE DRUG COMPOSITIONS FOR PULMONARY DELIVERY |
摘要 |
The present invention includes compositions and methods for making and using a rapid dissolving, high potency, substantially amorphous nanostructured aggregate for pulmonary delivery of tacrolimus and a stabilizer matrix comprising, optionally, a polymeric or non-polymeric surfactant, a polymeric or non-polymeric saccharide or both, wherein the aggregate comprises a surface area greater than 5 m2/g as measured by BET analysis and exhibiting supersaturation for at least 0.5 hours when 11-15-times the aqueous crystalline solubility of tacrolimus is added to simulated lung fluid. |
申请公布号 |
US2015224062(A1) |
申请公布日期 |
2015.08.13 |
申请号 |
US201514621337 |
申请日期 |
2015.02.12 |
申请人 |
Board of Regents, the University of Texas System |
发明人 |
WILLIAMS, III Robert O.;JOHNSTON Keith P.;SINSWAT Prapasri;MCCONVILLE Jason T.;TALBERT Robert;PETERS Jay I.;WATTS Alan B.;ROGERS True L. |
分类号 |
A61K9/51;A61K38/13;A61K9/00;A61K31/436 |
主分类号 |
A61K9/51 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Austin TX US |