VECTORS AND METHODS FOR ENHANCING RECOMBINANT PROTEIN EXPRESSION IN PLANTS.

摘要

Expression vectors and methods of their use for enhancing the production of recombinant proteins in plants or plant cells are described. Production can be further enhanced upon co-expression of the P19 suppressor of gene-silencing from tomato bushy stunt virus. Preferably, the recombinant proteins are therapeutic enzymes and/or antibodies and methods are carried out in Nicotiana benthamiana-optionally an RNAi-based glycomodified strain— or in the Nicotiana tabacum cultivar Little Crittenden.