5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocines as P2X7 modulators

摘要

The present invention is directed to a compound of Formula (I):;;The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.

主权项

1. A compound of formula I or an enantiomer or diastereomer thereof; or a pharmaceutically acceptable salt thereof; wherein: n is 1; X is CH2; R1 is phenyl or pyridinyl, wherein the phenyl or pyridinyl is optionally substituted with halogen or alkyl; and R2 is phenyl, pyridinyl, pyrazinyl, pyrimidinyl, pyrrolyl, pyrazolyl, thiazolyl or thiophenyl, wherein the phenyl, pyridinyl, pyrazinyl, pyrimidinyl, pyrrolyl, pyrazolyl, thiazolyl or thiophenyl is optionally substituted with halogen, alkyl, hydroxy or alkoxy.