Peptide derivatives for biofunctionalization of silicon substrates and their applications

摘要

The present invention relates to the use of a peptide consisting of 5 to 30 amino acid residues comprising an amino acid sequence selected from LLADTTHHRPWT (SEQ ID NO: 1), SPGLSLVSHMQT (SEQ ID NO: 2), and the sequences presenting at least 80% identity with SEQ ID NO: 1 or SEQ ID NO: 2, for the functionalization of silicon substrate. The present invention also relates to the specific peptides as such, and to silicon substrates functionalized by the adsorption on their surface of such specific peptides. Finally, the present invention is also directed to a process for the preparation of such functionalized silicon substrates, and to articles comprising a silicon substrate according to the invention.

主权项

1. A p-doped silicon substrate comprising a peptide adsorbed to the surface of the substrate, wherein the peptide consists of 5 to 30 amino acid residues, said peptide comprising an amino acid sequence selected from SEQ ID NO:2, and amino acid sequences with at least 80% sequence identity with SEQ ID NO:2, wherein optionally the peptide is covalently coupled at one end to a biological ligand.