Beta sheet tapes ribbons in tissue engineering

摘要

There is described a material comprising tapes, ribbons, fibrils or fibers characterized in that each of the ribbons, fibrils or fibers have an antiparallel arrangement of peptides in a β-sheet tape-like substructure wherein the material comprises a pair of self assembling complementary polypeptides.

主权项

1. A pair of self assembling complementary polypeptides (SACPs) that form tapes, ribbons, fibrils or fibres in a β-sheet tape-like substructure, when a first monomeric peptide is contacted or mixed with its complementary monomeric peptide and wherein each of the SACPs is 11 amino acid residues in length and wherein the SACPs comprise P11-13/14 (SEQ ID NOs: 2 and 3).