Buprenorphine transdermal therapeutic system and method of administering

摘要

The invention relates to transdermal therapeutic systems (TTS) comprising a backing, a reservoir layer containing at least one pharmaceutical active ingredient, and an adhesive. Said transdermal therapeutic systems are characterised in that they are able to continuously adhere to the surface of the skin over a long period of time. During said long period of time, a) there is at least one time interval during which the TTS adhering to the surface of the skin is intensively exposed to water, and b) the active ingredient is transdermally released. The invention also relates to a method for the continuous transdermal release of at least one pharmaceutical active ingredient over a long period of time.

主权项

1. A transdermal therapeutic system (TTS) comprising:
a backing layer comprising polyester; and a reservoir layer comprising:
buprenorphine as active pharmaceutical ingredient;a polymeric carrier material made of water-repelling polymers; andan adhesive which confers pressure-sensitive adhesive properties onto the reservoir layer; wherein the adhesive is configured to adhere continuously to the surface of a user's skin over a prolonged period of between at least 24 hours and of up to 168 hours; and wherein at least one time segment associated with intensive exposure to water of the TTS adhering to the surface of the skin occurs during the prolonged period; wherein the active ingredient buprenorphine is delivered transdermally during the prolonged period; wherein the adhesive comprises monomers selected from the group consisting of polysiloxanes, polyisobutylenes, and polyacrylates.