MK2 inhibitors

摘要

The present invention relates to compounds of general Formula (I) or a pharmaceutically acceptable salt thereof. The compounds can be used in the treatment of immune, autoimmune, inflammatory diseases, cardiovascular diseases, infectious diseases, bone resorption disorders, neurodegenerative diseases or proliferative diseases.;

主权项

1. A method of inhibiting MK2 activity comprising the step of contacting a cell with a compound selected from the group consisting of:
2′-(2-(benzofuran-2-yl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1H)-one; 2′-(2′-amino-2,5′-bipyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(2-(5-methoxypyridin-3-yl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(2-(2-fluorophenyl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(2-(3-fluorophenyl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(2-(4-acetylphenyl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(2-(benzo[d][1,3]dioxol-5-yl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; N-(5-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyrimidin-2-yl)pyridin-2-yl)acetamide; N-(5-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyrimidin-2-yl)pyridin-2-yl)propionamide; 2′-(2-(3-chloro-4-(trifluoromethyl)phenyl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(2-(3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(2-(biphenyl-4-yl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(2-(3,4-dichlorophenyl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(2-(3-isopropylphenyl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(2-(4-phenoxyphenyl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(2-(3-(trifluoromethoxy)phenyl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(2-(4-(trifluoromethyl)phenyl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(2-(4-cyclohexylphenyl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(2-(3-tert-butyl-5-methylphenyl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(2-(4-hydroxy-3-methoxyphenyl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(2-(quinolin-3-yl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(2-(4-tert-butylphenyl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(2-(4-isobutylphenyl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(2-(naphthalen-2-yl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(2-(3,5-dichlorophenyl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(2-(dibenzo[b,d]furan-2-yl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(2-(4-isobutoxyphenyl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(2-(benzo[b]thiophen-2-yl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 3-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyrimidin-2-yl)benzamide; 2′-(2-(3-acetylphenyl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2-chloro-N-cyclohexyl-4-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyrimidin-2-yl)benzamide; 2′-(2-(4-chloro-2-fluorophenyl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(2-(biphenyl-3-yl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(2-(3,5-bis(trifluoromethyl)phenyl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7 pyrrolo[3,2-c]pyridin]-4(1′H)-one; 2′-(2-(3-(trifluoromethyl)phenyl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; N-cyclohexyl-4-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyrimidin-2-yl)benzamide; 2′-(2-(benzofuran-2-yl)pyrimidin-4-yl)-1-methyl-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(2-(benzofuran-2-yl)pyrimidin-4-yl)-1-methyl-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(2-(benzofuran-2-yl)pyrimidin-4-yl)-1-ethyl-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 1-(2-aminoethyl)-2′-(2-(benzofuran-2-yl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; N-(2-(2′-(2-(benzofuran-2-yl)pyrimidin-4-yl)-4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridine]-1-yl)ethyl)acetamide; N-(3-(2′-(2-(benzofuran-2-yl)pyrimidin-4-yl)-4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridine]-1-yl)propyl)acetamide; 2′-(2-(benzofuran-2-yl)-5-fluoropyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(2-(benzo[d][1,3]dioxol-5-yl)-5-fluoropyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(5-fluoro-2-(quinolin-3-yl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 4-(5-fluoro-4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyrimidin-2-yl)-N-methylbenzamide; 2′-(2-(4-chloro-2-fluorophenyl)-5-fluoropyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(2-(benzofuran-2-yl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-3,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(2-(benzo[d][1,3]dioxol-5-yl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-3,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(2-(benzo[d][1,3]dioxol-5-yl)pyrimidin-4-yl)-5′,6′-dihydrospiro[pyrrolidine-3,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(2-p-tolylpyrimidin-4-yl)-5′,6′-dihydrospiro[pyrrolidine-3,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(2-(3-fluorophenyl)pyrimidin-4-yl)-5′,6′-dihydrospiro[pyrrolidine-3,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(2-(benzofuran-2-yl)pyridin-4-yl)-5′,6′-dihydrospiro[pyrrolidine-3,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(2-(benzofuran-2-yl)pyrimidin-4-yl)-5′,6′-dihydrospiro[morpholine-2,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(2-(benzofuran-2-yl)pyridin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(2-(quinolin-3-yl)pyridin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1H′)-one; 2′-(2-(benzo[d][1,3]dioxol-5-yl)pyridin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(2-(benzo[d]thiazol-2-yl)pyridin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(2-(benzo[d]thiazol-2-yl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(2-(thiazol-2-yl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 1-(2-aminoacetyl)-2′-(2-(benzofuran-2-yl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(2′-(cyclopentylamino)-2,5′-bipyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; N-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyridin-2-yl)-4-(trifluoromethyl)benzamide; 3,4-dimethyl-N-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyridin-2-yl)benzamide; N-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-3,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyrimidin-2-yl)-4-(trifluoromethyl)benzamide; N-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-3,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyrimidin-2-yl)-3-(trifluoromethoxy)benzamide; 2′-(2-(6-aminopyridin-3-yl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(2-(pyridin-3-yl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(2-(pyridin-3-yl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-3,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; (S)-2′-(2-(pyridin-3-yl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-3,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; (R)-2′-(2-(pyridin-3-yl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-3,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(2-(6-(3-methoxypropoxyl)pyridin-3-yl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-3,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; (S)-2′-(2-(6-(3-methoxypropoxyl)pyridin-3-yl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-3,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; (R)-2′-(2-(6-(3-methoxypropoxyl)pyridin-3-yl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-3,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(2-(5-methoxypyridin-3-yl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-3,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; (S)-2′-(2-(5-methoxypyridin-3-yl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-3,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; (R)-2′-(2-(5-methoxypyridin-3-yl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-3,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(2′-(cyclopentylamino)-2,5′-bipyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 3,4-dimethyl-N-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyrimidin-2-yl)benzamide; 3,4-dimethyl-N-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyridin-2-yl)benzamide; 3-fluoro-N-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyridin-2-yl)benzamide; 3-fluoro-N-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyridin-2-yl)benzamide; N-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyridin-2-yl)picolinamide; 4-fluoro-N-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyrimidin-2-yl)benzamide; 4-fluoro-N-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyridin-2-yl)benzamide; N-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyrimidin-2-yl)-2-naphthamide; N-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyridin-2-yl)-2-naphthamide; N-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyrimidin-2-yl)-1-naphthamide; N-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyridin-2-yl)-1-naphthamide; N-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyridin-2-yl)biphenyl-4-carboxamide; N-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyridin-2-yl)-4-(trifluoromethyl)benzamide; 3-(dimethylamino)-N-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyridin-2-yl)benzamide; N-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-4,T-pyrrolo[3,2-c]pyridine]-2′-yl)pyridin-2-yl)isonicotinamide; 6-methoxy-N-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyridin-2-yl)picolinamide; 3,4-dimethyl-N-(4-(1-methyl-4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyridin-2-yl)benzamide; 3,4-dimethyl-N-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-3,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyridin-2-yl)benzamide; (S)-3,4-dimethyl-N-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-3,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyridin-2-yl)benzamide; (R)-3,4-dimethyl-N-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-3,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyridin-2-yl)benzamide; 3,4-dimethyl-N-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[pyrrolidine-3,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyridin-2-yl)benzamide; N-(4-(1-methyl-4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyridin-2-yl)-3-(trifluoromethoxy)benzamide; N-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-3,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyridin-2-yl)-3-(trifluoromethoxy)benzamide; N-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[pyrrolidine-3,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyridin-2-yl)-3-(trifluoromethoxy)benzamide; 3-fluoro-N-(4-(1-methyl-4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyridin-2-yl)benzamide; 3-fluoro-N-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-3,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyridin-2-yl)benzamide; 3-fluoro-N-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[pyrrolidine-3,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyridin-2-yl)benzamide; 1 N-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-3,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyridin-2-yl)picolinamide; N-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[pyrrolidine-3,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyridin-2-yl)picolinamide; 4-fluoro-N-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-3,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyridin-2-yl)benzamide; (S)-4-fluoro-N-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-3,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyridin-2-yl)benzamide; (R)-4-fluoro-N-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-3,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyridin-2-yl)benzamide; 4-fluoro-N-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[pyrrolidine-3,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyridin-2-yl)benzamide; N-(4-(1-methyl-4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyridin-2-yl)-2-naphthamide; N-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-3,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyridin-2-yl)-2-naphthamide; (S)—N-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-3,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyridin-2-yl)-2-naphthamide; N-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[pyrrolidine-3,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyridin-2-yl)-2-naphthamide; N-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-3,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyridin-2-yl)-3-(trifluoromethyl)benzamide; 3,5-difluoro-N-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-3,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyridin-2-yl)benzamide; N-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-3,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyridin-2-yl)-1-naphthamide; N-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-3,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyridin-2-yl)quinoline-2-carboxamide; N-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-3,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyridin-2-yl)isoquinoline-1-carboxamide; N-(4-(4′-oxo-1′,4′,5′,6′-tetrahydrospiro[piperidine-3,7′-pyrrolo[3,2-c]pyridine]-2′-yl)pyridin-2-yl)-4-(trifluoromethyl)benzamide, and (S)-2′-(2-(benzo[d][1,3]dioxol-5-yl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-3,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one,or a pharmaceutically acceptable salt thereof.