| 发明名称 | Human monoclonal antibodies to protein tyrosine kinase 7 (PTK7) | ||
| 摘要 | The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PTK7 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PTK7, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PTK7 antibodies. | ||
| 申请公布号 | US9102738(B2) | 申请公布日期 | 2015.08.11 |
| 申请号 | US201213468624 | 申请日期 | 2012.05.10 |
| 申请人 | E. R. Squibb & Sons, L.L.C. | 发明人 | Terrett Jonathan Alexander;Lu Li-Sheng;Pan Chin |
| 分类号 | C07K16/40;C07K16/00;C07K16/30;A61K39/00 | 主分类号 | C07K16/40 |
| 代理机构 | Nelson Mullins Riley & Scarborough LLP | 代理人 | Nelson Mullins Riley & Scarborough LLP ;Remillard, Esq. Jane E.;Sloper, Esq. Jill Gorny |
| 主权项 | 1. An isolated monoclonal antibody, or an antigen-binding portion thereof, wherein the antibody specifically binds to human protein tyrosine kinase 7 (PTK7) and comprises: a) a heavy chain variable region CDR1 comprising SEQ ID NO:13; b) a heavy chain variable region CDR2 comprising SEQ ID NO:17; c) a heavy chain variable region CDR3 comprising SEQ ID NO:21; d) a light chain variable region CDR1 comprising SEQ ID NO:26; e) a light chain variable region CDR2 comprising SEQ ID NO:32; and f) a light chain variable region CDR3 comprising SEQ ID NO:38. | ||
| 地址 | Princeton NJ US | ||