ANTI-BV8 ANTIBODIES AND USING THEM

摘要

FIELD: medicine, pharmaceutics.SUBSTANCE: present invention refers to biotechnology. There are presented versions of human or macaque anti-Bv8 antibodies, each of which is characterised by the fact that it contains 6 CDR. What is described is a coding nucleic acid; a based expression vector for producing the antibody; a host cell for expressing the vector-based antibodies, as well as a method for producing the antibody with using the cell. There are disclosed a pharmaceutical composition using the antibody in an effective amount, as well as using the antibody for treating tumour, cancer or disturbed cell proliferation. What is presented is using the antibody for reducing or inhibiting angiogenesis in an individual, as well as for inhibiting endothelial cell proliferation.EFFECT: using the invention provides the human or macaque Bv8 affine antibodies (K) of less than 10M as measured by BIACORE 3000 technique, which can find application in therapy of various cancer diseases.25 cl, 43 dwg, 1 tbl, 3 ex