Compositions for Repair of Defects in Osseous Tissues, and Methods of Making the Same

摘要

Tissue repair compositions, particularly bone repair compositions, containing demineralized bone fragments and homogenized connective tissues, and methods for making the same. The compositions can be used in the form of an injectable gel, an injectable paste, a paste, a putty, or a rehydratable freeze-dried form.

主权项

1. A method of preparing a tissue repair composition comprising,
providing at least one connective tissue and at least one bone tissue from at least one cadaver, freeze-drying the connective tissue, crudely fragmenting the connective tissue, adding at least one of water, an aqueous solution; or a water miscible polar organic solvent to the crude fragments to produce a mixture, homogenizing the mixture to produce a connective tissue homogenate, fragmenting the bone tissue, demineralizing the bone fragments, freeze-drying the demineralized bone fragments, selecting demineralized bone fragments of a particular range, and combining the selected demineralized bone fragments with the connective tissue homogenate to produce the tissue repair composition.