发明名称 |
RECOMBINANT CELL SURFACE CAPTURE PROTEINS. |
摘要 |
<p>Recombinant cell surface capture proteins and detection molecules that are useful for isolating and detecting cells that produce a secreted heterodimeric protein of interest (POI) that has an immunoglobulin CH3 domain and/or substituted CH3 domain are provided. Recombinant cell surface capture proteins and detection molecules that isolate and detect bispecific antibodies are also provided. The invention also provides recombinant antigen-binding proteins that are capable of recognizing and binding to proteins of interest that contain a CH3 domain and/or a modified CH3 domain, such as a CH3 domain with or without amino acid substitutions at H95 and Y96 (IMGT).</p> |
申请公布号 |
MX2015006112(A) |
申请公布日期 |
2015.08.06 |
申请号 |
MX20150006112 |
申请日期 |
2013.11.14 |
申请人 |
REGENERON PHARMACEUTICALS, INC. |
发明人 |
GANG CHEN;DARYA BURAKOV;DIPALI DESHPANDE;JAMES FANDL;THOMAS ALDRICH;VISHAL KAMAT |
分类号 |
C07K16/18;C07K16/42;C12N15/10 |
主分类号 |
C07K16/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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