发明名称 |
Drug delivery system for administration of a water soluble, cationic and amphiphilic pharmaceutically active substance |
摘要 |
<p>A drug delivery system (DDS) for administration of a water soluble, cationic, and amphiphilic pharmaceutically active substance (API) which DDS comprises amorphous particles of <100 nm of a poorly water soluble complex of the API with a Na-salt of N-all-trans-retinoyl cysteic acid methyl ester and/or a Na-salt of N-13- cis-retinoyl cysteic acid methyl ester, which particles are entrapped in nanoparticles formed a Na-salt of N-all-trans-retinoyl cysteic acid methyl ester and/or a Na- salt of N-13-cis-retinoyl cysteic acid methyl ester, the w/w-ratio of Na-salt of N-alltrans-retinoyl cysteic acid methyl ester and/or a Na-salt of N-13-cis-retinoyl cysteic acid methyl ester to the complex is about 0.5:1 to about 20:1. A pharmaceutical composition comprising such a DDS. Methods for preparation of such a DDS and such a pharmaceutical composition. Use of such a DDS and pharmaceutical composition for treatment of cancer.</p> |
申请公布号 |
AU2008339101(B2) |
申请公布日期 |
2015.08.06 |
申请号 |
AU20080339101 |
申请日期 |
2008.12.18 |
申请人 |
ARDENIA INVESTMENTS, LTD. |
发明人 |
ALEKSOV, JULIAN;LOKOT, IGOR |
分类号 |
A61K47/48;A61K9/14;A61P35/00 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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