DEVICES AND METHODS FOR PARAHYDROGEN INDUCED POLARIZATION

摘要

The present invention teaches devices and methods for hyperpolarization by parahydrogen induced polarization. The invention teaches several significant improvements over previous designs, including a heating block, an enhanced solenoid component, and pinch valves and tubing that provide a sterile environment for the sample. All of these advancements can be accomplished while keeping costs to produce the device relatively low.

主权项

1. A device for parahydrogen induced polarization, comprising:
(1) a reactor, comprising a first reactor inlet, a second reactor inlet, and a reactor outlet; (2) a precursor receiving tube, comprising a first precursor receiving tube end and a second precursor receiving tube end, wherein the first precursor receiving tube end is mechanically connected to the first reactor inlet; (3) a parahydrogen receiving tube, comprising a first parahydrogen receiving tube end and a second parahydrogen receiving tube end, wherein the first parahydrogen receiving tube end is mechanically connected to the second reactor inlet; (4) an outlet tube, comprising a first outlet tube end and a second outlet tube end, wherein the first outlet tube end is mechanically connected to the reactor outlet; (5) a radio frequency (RF) coil enveloping the reactor along the vertical axis thereof; (6) a solenoid coil enveloping the RF coil along the vertical axis thereof; and (7) a metal heating block, comprising a longitudinal axis comprising a plurality of grooves situated perpendicular thereto, wherein each of the plurality of grooves are configured to accommodate a section of the precursor receiving tube, and wherein the section of the precursor receiving tube is wrapped around the grooves of the metal heating block.