发明名称 |
METHODS, KITS AND COMPOSITIONS FOR PROVIDING A CLINICAL ASSESSMENT OF PROSTATE CANCER |
摘要 |
The present invention relates to prostate cancer signatures which are useful for providing a clinical assessment of prostate cancer from a biological sample of a subject. By performing initial gene expression studies on urine samples from prostate cancer and non-prostate cancer subjects, and using the PCA3/PSA prostate cancer test as a performance benchmark, the present inventors have surprisingly discovered multiple signatures that are informative in urine-based prostate cancer tests, as well as in tissue-based tests. The signatures relate to combinations of at least two prostate cancer markers whose expression pattern in urine has been validated as being associated (either positively or negatively) with a clinical assessment of prostate cancer. The prostate cancer markers can be used in conjunction with bioinformatics approaches to generate a prostate cancer score, which correlates with a clinical assessment of prostate cancer. Methods, kits and compositions relating to the aforementioned signatures are also described. |
申请公布号 |
US2015218646(A1) |
申请公布日期 |
2015.08.06 |
申请号 |
US201314416036 |
申请日期 |
2013.06.14 |
申请人 |
DIAGNOCURE INC. |
发明人 |
Haince Jean-François;Beaudry Guillaume;Fradet Yves;Paquet Éric |
分类号 |
C12Q1/68;G06F19/00 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
1. A method for providing a clinical assessment of prostate cancer in a subject, said method comprising:
(a) determining the expression of at least two prostate cancer markers listed in Table 5 or 6A, or a marker co-regulated therewith in prostate cancer, in a biological sample from said subject; (b) normalizing the expression of said at least two prostate cancer markers using one or more control markers; (c) performing a mathematical correlation of the normalized expression levels of said at least two prostate cancer markers; (d) deriving a score from said mathematical correlation; and (e) providing said clinical assessment of prostate cancer based on said derived score. |
地址 |
Québec CA |