发明名称 |
COMPOSITIONS FOR MODULATING GENE EXPRESSION |
摘要 |
Aspects of the invention provide methods for selecting a candidate oligonucleotide for activating expression of a target gene. Further aspects of the invention provide methods of selecting a set of oligonucleotides that is enriched in oligonucleotides that activate expression of a target gene. Further aspects provide single stranded oligonucleotides that modulate gene expression and compositions and kits comprising the same. Methods for modulating gene expression using the single stranded oligonucleotides are also provided. |
申请公布号 |
US2015218560(A1) |
申请公布日期 |
2015.08.06 |
申请号 |
US201514691361 |
申请日期 |
2015.04.20 |
申请人 |
RaNA Therapeutics, Inc. ;The General Hospital Corporation d/b/a Massachusetts General Hospital |
发明人 |
Krieg Arthur M.;Subramanian Romesh;McSwiggen James;Lee Jeannie T. |
分类号 |
C12N15/113 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Cambridge MA US |