| 发明名称 |
METHODS OF TREATING CANCER USING PD-1 AXIS BINDING ANTAGONISTS AND TIGIT INHIBITORS |
| 摘要 |
The present invention describes combination treatment comprising a PD-1 axis binding antagonist and an agent that decreases or inhibits TIGIT expression and/or activity and methods for use thereof, including methods of treating conditions where enhanced immunogenicity is desired such as increasing tumor immunogenicity for the treatment of cancer or chronic infection. |
| 申请公布号 |
US2015216970(A1) |
申请公布日期 |
2015.08.06 |
| 申请号 |
US201414333375 |
申请日期 |
2014.07.16 |
| 申请人 |
GENENTECH, INC. |
发明人 |
GROGAN Jane;JOHNSTON Robert J.;IRVING Bryan;HACKNEY Jason;YU Xin;EATON Dan;BOWLES Kristin;COMPS-AGRAR Laetitia |
| 分类号 |
A61K39/395;A61K45/06 |
主分类号 |
A61K39/395 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for treating or delaying progression of cancer in an individual comprising administering to the individual an effective amount of a PD-1 axis binding antagonist and an agent that decreases or inhibits TIGIT expression and/or activity. |
| 地址 |
South San Francisco CA US |
