| 主权项 |
1. A compound having the structure:wherein:
R1 is H, or a C1-C6 alkyl, C3-C6 alkenyl, C3-C6 cycloalkyl or C3-C6 cycloalkenyl which is unsubstituted or substituted with a hydroxyl group or a C1-C6 alky; R2 is H, or a C1-C3 alkyl; or R1 and R2 form a C3-C6 heterocyclic ring with the nitrogen bonded to said R1 and R2; R3 is:in which:
R4 is H, or a C1-C6 alkyl, C3-C6 alkenyl, C3-C6 cycloalkyl or C3-C6 cycloalkenyl; R5 is a C1-C6 alkyl, C1-C6 alkoxy, or C2-C6 alkyl ether which is unsubstituted or substituted with one or more of hydroxyl, phenyl, phenyloxy, or fluorine, or R5 is NR7R8, or C(O)NR7R8 in which R7 and R8 are independently selected from H, a C1-C6 alkyl, C3-C6 alkenyl, C3-C6 cycloalkyl or C3-C6 cycloalkenyl; R6 is H, or a C1-C6 alkyl, C3-C6 alkenyl, C3-C6 cycloalkyl or C3-C6 cycloalkenyl; n is 0, 1, 2, 3, or 4; position a is —CH2—, —C(CH3)—, —C(CH3)2—, O or NR9 where R9 is H, OH, or a C1-C6 alkyl; position b is —CH2—, —CH(CH3)—, —C(CH3)2—, O, S, or NR10 where R10 is H, OH, or a C1-C6 alkyl; wherein position a and b are not both heteroatoms; m is 0, 1, 2, 3, or 4; wherein when m is 0, then position b is a carbon; p is 1, 2, or 3; or a pharmaceutically acceptable salt thereof. |
