发明名称 |
FINGOLIMOD HYDROCHLORIDE PROCESS |
摘要 |
A process for preparation of diethyl 2-acetamido-2-(4-octyI phenyl)ethyl malonate (III), a key intermediate of fingolimod hydrochloride comprising reaction of 2-(4-octylphenyl)ethyl iodide (IV) with diethyl acetamido malonate in presence of a base and an iodinating agent and in an organic solvent. The compound of formula (III) thus obtained provided fingolimod hydrochloride (la) is having associated impurities below the regulatory limits. |
申请公布号 |
IN3696MU2013(A) |
申请公布日期 |
2015.07.31 |
申请号 |
IN2013MUM3696 |
申请日期 |
2013.11.25 |
申请人 |
EMCURE PHARMACEUTICALS LIMITED |
发明人 |
GURJAR MUKUND KESHAV;TRIPATHY NARENDRA KUMAR;NEELAKANDAN KALIAPERUMAL;PANCHABHAI PRASAD PANDURANG;SRINIVAS NANDALA;BALASUBRAMANIAN PRABHAKARAN;BUCHUDE SANDIP BAJABA;MUGALE BALAJI RAM;AHIRRAO PRAVIN PRABHAKAR;MEHTA SAMIT SATISH |
分类号 |
C07C215/20 |
主分类号 |
C07C215/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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