METHODS, SYSTEMS, AND DEVICES FOR POSITIVE PRESSURE PHARMACEUTICAL VIALS

摘要

Methods, systems, and devices are described for calculating a push pressure for a pharmaceutical vial with a syringe, the method including accepting data regarding at least one parameter of the pharmaceutical vial, at least one parameter of a vial cap with a seal, at least one parameter of the syringe, and a single dose volume of a liquid pharmaceutical; calculating a volume of headspace over the liquid pharmaceutical with a computing device; calculating an ejection pressure based on the single dose volume of the liquid pharmaceutical and the volume of headspace; calculating a motive pressure based on a static force and a cross-sectional area of the syringe; defining the push pressure as the greater of the ejection pressure or the motive pressure; and reporting the push pressure to a user. The method further includes calculating a molar amount of inert gas needed in the pharmaceutical vial to generate the calculated push pressure.

主权项

1. A method of calculating a push pressure of a pharmaceutical vial with a syringe comprising:
accepting data including at least one parameter of the pharmaceutical vial, the at least one parameter of the pharmaceutical vial including an internal volume of the pharmaceutical vial; accepting data including a single dose volume of a liquid pharmaceutical; accepting data including at least one parameter of a vial cap with a seal, the at least one parameter of the vial cap with the seal including a volume of the vial cap; calculating a volume of headspace over the single dose volume of the liquid pharmaceutical with a computing device; calculating an ejection pressure with the computing device based on the single dose volume of the liquid pharmaceutical and the volume of headspace; accepting data including at least one parameter of the syringe, the at least one parameter of the syringe including a static force and a cross-sectional area of the syringe; calculating a motive pressure with the computing device based on the static force and the cross-sectional area of the syringe; defining the push pressure as the greater of the ejection pressure or the motive pressure; and reporting the push pressure to a user.