SUBSTITUTED TRIAZOLOPYRIDINES AND THEIR USE AS TTK INHIBITORS

摘要

The present invention relates to substituted triazolopyridine compounds of general formula (I):;;in which R1, R2, R3, R4, and R5 are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.

主权项

1. A compound of general formula (I): in which: R1 represents wherein * indicates the point of attachment of said group with the rest of the molecule; R2 represents wherein * indicates the point of attachment of said group with the rest of the molecule; R3 represents a hydrogen atom; R4 represents a hydrogen atom; R5 represents a hydrogen atom or a C1-C3-alkyl- group; R5a represents a group selected from: C1-C4-alkoxy-, halo-C1-C4-alkoxy-, C1-C4-alkyl; R5b represents a group selected from:
—C(═O)N(H)R8, —C(═O)NR8R7, —N(R7)C(═O)OR8, R7—S(═O)2—; R6 represents a wherein * indicates the point of attachment of said group with the rest of the molecule;wherein said group is optionally substituted, one or more times, identically or differently, with a halogen atom or a methyl- group; R7 represents a C1-C3-alkyl- or a cyclopropyl- group; R8 represents a hydrogen atom or a C1-C6-alkyl- or C3-C6-cycloalkyl- group, wherein said C1-C6-alkyl- or C3-C6-cycloalkyl- group is optionally substituted, one or more times, with a halogen atom; or R7 and R8 together with the molecular fragment they are attached to represent a 4- to 6-membered heterocyclic ring, which is optionally substituted, one or more times, identically or differently, with a halogen atom, a C1-C3-alkyl-, halo-C1-C3-alkyl- or C1-C3-akloxy- group; R9 represents a group selected from: C1-C3-alkyl-, hydroxy-C1-C3-alkyl-, —N(H)R8; —N(R7)R8, N(H)(R8)—C1-C3-alkyl-, N(R7)(R8)—C1-C3-alkyl-; and Q represents CH or N; or a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.