Method for preparing a conjugate comprising a granulocyte colony stimulating factor protein and a hydroxyalkyl starch polymer derivative and various aspects related thereto

摘要

The present invention relates to conjugates of hydroxyalkyl starch and a granulocyte colony stimulating factor protein (G-CSF) wherein these conjugates are formed by a covalent linkage between the hydroxyalkyl starch or a derivative of the hydroxyalkyl starch and the protein. The present invention also relates to the methods of producing these conjugates and the use of these conjugates.