| 主权项 |
1. A compound, or a pharmaceutically acceptable salt, hydrate or solvate thereof, of Formula (I): wherein: Ar is chosen from aryl and heteroaryl, wherein Ar may be optionally substituted with one or more R6 substituents; R2 is chosen from hydrogen, halo and C1-4 alkyl; R3 is chosen from hydrogen, halo and C1-4 alkyl; R4 is chosen from cyano, C(O)CH2R2, C(O)CF3, C(O)CH═CH2, C(O)CR7═CH2, C(O)CH═CHR7, C(O)CR7═CHR7, C(O)CH═CR7R7, C(O)CH═CHCH2R8, C(O)CH═CHC(O)CH2R8, C(O)C(CN)═CH2, C(O)(C(O)NH2)C═CH2, S(O)2CH═CH2, (CH2)mCR7═CR9C(O)Me, (CH2)mCR7═CR9C(O)NH2, (CH2)mCR7═CR9C(O)NHR7, (CH2)mCR7═CR9C(O)N(R7)2, and (CH2)mCR7═CR9CN; R5 is chosen from hydrogen, —(CH2)nC3-7 cycloalkyl, and C1-4 alkyl; each R6 is independently chosen from hydrogen, C1-4 alkyl, —(CH2)nC3-7 cycloalkyl, OC1-4 alkyl, C1-4 alkylamino, NH2, NHC1-4 alkyl, N(C1-4 alkyl)2, cyano, C(O)NH2, C(O)NHR5, C(O)N(R5)2, C(O)C1-4 alkyl, trifluoromethyl, halo, —(CH2)nC3-7 cycloalkyl, C(O)NHaryl, and C(O)NHheteroaryl, wherein aryl and heteroaryl may be optionally substituted with one or more R9; each R7 is independently chosen from hydrogen, CN, C1-4 alkyl, C3-7 cycloalkyl, C3-7 heterocycle, aryl, and heteroaryl wherein aryl and heteroaryl may be optionally substituted with one or more R9; R8 is chosen from hydrogen, C1-4 alkyl, C1-4alkylaryl, C1-4alkyl-O-aryl, C1-4 alkylheteroarylaryl, C3-7 cycloalkyl, C3-7 heterocycle, OH, OC1-4 alkyl, C1-4 alkylOC1-4 alkyl, NH2, NHC1-4 alkyl, N(C1-4 alkyl)2, heterocycle, aryl and heteroaryl, wherein each aryl and heteroaryl may be optionally substituted with one or more R9; R9 is chosen from hydrogen, C1-4 alkyl, CN, CF3, C(O)Me, C(O)NH2, and aryl; X is chosen from N and CR3; m is chosen from 1, 2 and 3; and n is chosen from 0, 1, 2, and 3. |
