DOSAGE FORM COMPRISING AN ACTIVE INGREDIENT AND A PLURALITY OF SOLID POROUS MICROCARRIERS

摘要

The present application provides a dosage form and related methods for making the dosage form. The dosage form generally comprises a hydrophilic active ingredient, a plurality of solid, porous microcarriers, each having a hydrophobic surface, an optional hydrophobic encapsulant, and a hydrophilic delivery agent, wherein (i) the hydrophilic active ingredient is associated with the plurality of solid, porous microcarriers, (ii) the plurality of solid, porous microcarriers is encapsulated by the hydrophobic encapsulant, and (iii) the hydrophilic delivery agent is physically separated from a majority of the hydrophilic active ingredient by a boundary between the hydrophilic delivery agent and the hydrophobic encapsulant. In some embodiments, the dosage form is for topical application. In some additional embodiments, the plurality of solid, porous microcarriers is formed by modifying the microcarriers to increase their hydrophobicity.

主权项

1. A method for fabricating a dosage form comprising the steps of
(i) providing a plurality of hydrophobic microcarriers, (ii) dissolving one or more active ingredients in a solvent to form a first solution, adding the plurality of hydrophobic microcarriers to the first solution and mixing to form a first mixture, (iii) removing the solvent from the first mixture via heat or reduced pressure to form a second mixture, and (iv) mixing the second mixture with a hydrophobic encapsulant and a hydrophilic delivery agent to form the dosage form.