Specific nNOS inhibitors for the therapy and prevention of human melanoma

摘要

Methods for melanoma treatment and prevention with selective nitric oxide synthase inhibitor compounds and related pharmaceutical compositions, alone or in conjunction with one or more other melanoma therapies.

主权项

1. A method of reducing expression of neuronal nitric oxide synthase, said method comprising:
providing a compound selected from compounds of a formulawherein R1 is selected from H, halogen, methyl and halomethyl moieties; R2 is selected from H, alkyl and haloalkyl moieties; Z is selected from O and NH; and R4 is selected from H, alkyl, halogen and haloalkyl moieties, and salts thereof; and
contacting said compound with a cellular medium comprising one of human melanocytes, melanoma cells and a combination thereof, said compound in an amount sufficient to reduce induction of neuronal nitric oxide synthase expression, thereby reducing ultra-violet induced nitric oxide production in a human melanocyte or melanoma cell.