Anti-virus therapy for respiratory diseases

摘要

The present invention provides the use of IFN-β, an agent that increases the expression of IFN-β, or a polynucleotide which is capable of expressing IFN-β or said agent for the manufacture of a medicament for the treatment of rhinovirus-induced exacerbation of a respiratory disease selected from asthma and chronic obstructive pulmonary disease, wherein said treatment is by airway delivery of said medicament, e.g. by use of an aerosol nebuliser. Also provided is IFN-λ for the same purpose.

主权项

1. A method of treating a patient with a viral-induced exacerbation of a respiratory disorder, the method comprising: administering to the patient a therapeutically effective amount of an agent, wherein the agent comprises:
(a) an interferon-λ (IFN-λ) polypeptide or (b) a polynucleotide which expresses an IFN-λ polypeptide in a target bronchial epithelial cell, wherein the administration results in suppression of viral replication causing said viral-induced exacerbation in the patient, and said respiratory disorder is asthma or chronic obstructive pulmonary disease (COPD).