Apparatuses, systems, and methods for filling a container with a liquid drug

摘要

In one embodiment, a method of filling a container with a liquid drug from a drug reservoir may include: a) connecting a container and a drug reservoir with a cannula such that the drug reservoir and the container fluidically communicate with each other via the cannula, while being hermetically sealed; b) reducing a first volume contained within the container to displace a gaseous medium from the first volume of the container via the cannula into a second volume contained within the drug reservoir; c) increasing the first volume of the container to displace the liquid drug from the second volume of the drug reservoir into the first volume of the container to fill the container; and d) disconnecting the container and the drug reservoir. Before performing action d), action b) and action c) can be successively performed more than once to stepwise increase an amount of liquid drug displaced.

主权项

1. A method of automatically filling a container with a liquid drug from a drug reservoir, the method comprising:
a) connecting a container and a drug reservoir with a cannula such that the drug reservoir and the container fluidically communicate with each other via the cannula, while being hermetically sealed; b) reducing a first volume contained within the container to displace a gaseous medium from the first volume of the container via the cannula into a second volume contained within the drug reservoir by activating a drive coupled to the container; c) increasing the first volume of the container to displace liquid drug from the second volume of the drug reservoir into the first volume of the container to fill the container; and d) disconnecting the container and the drug reservoir, wherein action b) and action c) are successively performed more than once to stepwise increase an amount of liquid drug displaced to the first volume of the container; and wherein: action b) and action c) are successively performed more than once before performing action d) to reduce the risk of formation of foam and/or air bubbles within the liquid drug that is filled into the container; and during each performance of b) and c) the drug reservoir is arranged above the container; wherein action (d) is performed after sensing a fill level with a sensor directly attached to and linearly extending out from a circuit board, the sensor coupled to the drive and after sending of a signal by the sensor to the drive to deactivate the drive, the sensor is triggered to deactivate the drive once a magnetic element coupled to the drive is positioned in front of the sensor and between the sensor and a pinion; and wherein actions b) and c) comprise movement of a piston rod moving a piston displaceable within the container, the magnetic element being coupled to the pinion rotating with each stroke of the piston.