| 发明名称 | Stabilization of vitamin B<sub>12 </sub> | ||
| 摘要 | The invention relates to preparations comprising vitamin B12 and a butanol, and to the use of butanol for stabilizing vitamins. | ||
| 申请公布号 | US9089582(B2) | 申请公布日期 | 2015.07.28 |
| 申请号 | US201012951581 | 申请日期 | 2010.11.22 |
| 申请人 | Bayer Intellectual Property GMBH | 发明人 | Heep Iris;Taterra Hans-Rolf |
| 分类号 | A61K31/714;A61P43/00;A61K31/66;A61K9/00;A61K31/662;A61K47/10 | 主分类号 | A61K31/714 |
| 代理机构 | Senniger Powers LLP | 代理人 | Senniger Powers LLP |
| 主权项 | 1. A method of stabilizing a vitamin B12 formulation to light, the method comprising: dissolving an amount of vitamin B12 in water by heating to form a vitamin B12 solution, mixing the vitamin B12 solution with butaphosphan and n-butanol to form a stock solution, and adjusting the stock solution to a pH of from about 4 to about 7 by adding an acid or a base to form the vitamin B12 formulation, wherein the vitamin B12 formulation comprises from 0.001 to 0.01% m/V vitamin B12 and from 0.5 to 7% m/V n-butanol. | ||
| 地址 | DE | ||