Treatment of tissue adhesion

摘要

Dry powder compositions are useful in the treatment or prevention of tissue adhesions during or after surgery or during wound therapy. The dry powder compositions may contain trehalose. The dry powder compositions may be fibrin sealant compositions comprising fibrinogen and/or thrombin.

主权项

1. A method comprising:
reducing or preventing tissue adhesion formation between organs or between organs and other tissues in a subject after a surgical procedure, wherein the surgical procedure is selected from a group consisting of gynecological reproductive surgery, abdominal surgery, spinal and laparoscopic surgery, hepatic surgery, neurosurgical procedures and orthopedic procedures, by administering an effective amount of a dry powder composition comprising fibrinogen, thrombin and trehalose, or isomers or salts thereof, to exposed or separated tissues during the surgical procedure, wherein the dry powder composition contains about 0.5 to 20% w/w fibrinogen and about 25 to 1000 IU/g thrombin.