Methods and devices for delivering GLP-1 and uses thereof

摘要

The invention provides various devices for delivering Glucagon-Like Peptide-1 (7-36), in various infusion patterns and rates, to optimally stimulate carbohydrate metabolism, to inhibit gastropancreatic secretion and gastric motility, and to treat various disease conditions (including diabete) as described in the instant specification. The devices and methods of the invention provide various ways to deliver doses (escalating, constant, on demand, etc.) of GLP-1 in response to different patient need.

主权项

1. A device for delivering an effective amount of a GLP-1 compound to a patient in need of GLP-1 receptor stimulation comprising:
(a) a fluid storage chamber containing a GLP-1 compound, said fluid storage chamber having an output orifice through which said GLP-1 compound can be expelled; (b) a pump chamber functionally connected to said fluid storage chamber by a moveable barrier, wherein the rate of movement of said moveable barrier caused by said pump chamber is adjustable to produce variable dosing under patient control; (c) a hydraulic fluid reservoir functionally connected to a first actuator and having a high viscosity fluid stored therein, said hydraulic fluid reservoir fluidly connected to said pump chamber by a fixed aperture; and (d) a second actuator which physically acts on said pump chamber, wherein said second actuator is controlled independently of said first actuator; wherein said pump chamber continuously expands upon actuation of said device with said first actuator; wherein operating said first actuator causes said high viscosity fluid to flow into said pump chamber through said fixed aperture at a constant rate, thereby displacing said moveable barrier to compress said fluid storage chamber and causing a quantity of said GLP-1 compound to be expelled through said orifice; wherein operating said second actuator independently causes displacement of said moveable barrier to compress said fluid storage chamber, thereby causing a quantity of said GLP-1 compound to be expelled; and wherein concurrently operating both of said first and second actuators causes displacement of the moveable barrier to compress said fluid storage chamber at an increased rate relative to operating either actuator alone.