主权项 |
1. A compound represented by the formula (1) or a pharmaceutically acceptable salt thereof:wherein m is 2, l is 1 and n is 1; X represents —CH2—;R1 represents hydrogen, a C1-C6 alkyl group, a hydroxy C1-C6 alkyl group, a protecting group selected from unsubstituted C1-C6 alkanoyl, phthaloyl, C1-C6 alkoxycarbonyl, unsubstituted aralkyloxycarbonyl, 9-fluorenylmethoxycarbonyl, nitrophenylsulfenyl, aralkyl and C1-C6 alkylsilyl groups, or a tri C1-C6 alkylsilyloxy C1-C6 alkyl group;R2 and R3, which are the same or different, each independently represent hydrogen or a C1-C6 alkyl group; or R2 and R3 are bonded to form a cyclo-C3-C8 alkyl group; andR4 represents any of(1) a phenyl group,(2) an indolyl group,(3) a benzothienyl group,(4) a naphthyl group,(5) a benzofuryl group,(6) a quinolyl group,(7) an isoquinolyl group,(8) a pyridyl group,(9) a thienyl group,(10) a dihydrobenzoxazinyl group,(11) a dihydrobenzodioxinyl group,(12) a dihydroquinolyl group,(13) a chromanyl group,(14) a quinoxalinyl group,(15) a dihydroindenyl group,(16) a dihydrobenzofuryl group,(17) a benzodioxolyl group,(18) an indazolyl group,(19) a benzothiazolyl group,(20) an indolinyl group,(21) a thienopyridyl group,(22) a tetrahydrobenzazepinyl group,(23) a tetrahydrobenzodiazepinyl group,(24) a dihydrobenzodioxepinyl group,(25) a fluorenyl group,(26) a pyridazinyl group,(27) a tetrahydroquinolyl group,(28) a carbazolyl group,(29) a phenanthryl group,(30) a dihydroacenaphthylenyl group,(31) a pyrrolopyridyl group,(32) an anthryl group,(33) a benzodioxinyl group,(34) a pyrrolidinyl group,(35) a pyrazolyl group,(36) an oxadiazolyl group,(38) a tetrahydronaphthyl group,(39) a dihydroquinazolinyl group,(40) a benzoxazolyl group,(41) a thiazolyl group,(42) a quinazolinyl group,(43) a phthalazinyl group,(44) a pyrazinyl group, and(45) a chromenyl group, wherein these aromatic or heterocyclic groups may have 1 to 4 substituent(s) selected from(1-1) a halogen atom,(1-2) a C1-C6 alkyl group,(1-3) a C1-C6 alkanoyl group,(1-4) a halogen-substituted C1-C6 alkyl group,(1-5) a halogen-substituted C1-C6 alkoxy group,(1-6) a cyano group,(1-7) a C1-C6 alkoxy group,(1-8) a C1-C6 alkylthio group,(1-9) an imidazolyl group,(1-10) a tri C1-C6 alkylsilyl group,(1-11) an oxadiazolyl group which may have one or more C1-C6 alkyl group(s),(1-12) a pyrrolidinyl group which may have one or more oxo group(s),(1-13) a phenyl group which may have one or more C1-C6 alkoxy group(s),(1-14) a C1-C6 alkylamino C1-C6 alkyl group,(1-15) an oxo group,(1-16) a pyrazolyl group which may have one or more C1-C6 alkyl group(s),(1-17) a thienyl group,(1-18) a furyl group,(1-19) a thiazolyl group which may have one or more C1-C6 alkyl group(s),(1-20) a C1-C6 alkylamino group,(1-21) a pyrimidyl group which may have one or more C1-C6 alkyl group(s),(1-22) a phenyl C2-C6 alkenyl group,(1-23) a phenoxy group which may have one or more halogen atom(s),(1-24) a phenoxy C1-C6 alkyl group,(1-25) a pyrrolidinyl C1-C6 alkoxy group,(1-26) a C1-C6 alkylsulfamoyl group,(1-27) a pyridazinyloxy group which may have one or more C1-C6 alkyl group(s),(1-28) a phenyl C1-C6 alkyl group,(1-29) a C1-C6 alkylamino C1-C6 alkoxy group,(1-30) an imidazolyl C1-C6 alkyl group,(1-31) a phenyl C1-C6 alkoxy group,(1-32) a hydroxy group,(1-33) a C1-C6 alkoxycarbonyl group,(1-34) a hydroxyl C1-C6 alkyl group,(1-35) an oxazolyl group,(1-36) a piperidyl group,(1-37) a pyrrolyl group,(1-38) a morpholinyl C1-C6 alkyl group,(1-39) a piperazinyl C1-C6 alkyl group which may have one or more C1-C6 alkyl group(s),(1-40) a piperidyl C1-C6 alkyl group,(1-41) a pyrrolidinyl C1-C6 alkyl group,(1-42) a morpholinyl group, and(1-43) a piperazinyl group which may have one or more C1-C6 alkyl group(s). |