Anionic oil-in-water emulsions containing prostaglandins and uses thereof

摘要

A colloidal anionic oil-in-water emulsion includes a prostaglandin, an oil having a iodine value ≦2, a surfactant and water, provided the anionic oil-in-water emulsion does not contain polyvinyl alcohol. The use of the anionic oil-in-water emulsions for enhancing the stability of the prostaglandins, for the treatment of ocular hypertension and/or glaucoma, for promoting growth of eyelashes and/or for treating eyelash hypotrichosis is also described.

主权项

1. A colloidal oil-in-water emulsion comprising
a prostaglandin F2alpha an oil having a iodine value ≦2, a non-ionic surfactant selected from the group consisting of poloxamers, tyloxapol, polysorbates, sorbitan esters, polyoxyl stearates and mixtures thereof, and water,wherein the non-ionic surfactant, the amount of which is comprised between 0.0005 and 1% in weight by weight of said emulsion, releases negative charges during the manufacturing process of the emulsion, said emulsion having a negative zeta potential lower than −10 mV, said emulsion not containing polyvinyl alcohol, and said emulsion being free of cationic surfactant.