发明名称 |
Formulation of indomethacin |
摘要 |
The present invention relates to methods for producing particles of indomethacin using dry milling processes as well as compositions comprising indomethacin, medicaments produced using indomethacin in particulate form and/or compositions, and to methods of treatment of an animal, including man, using a therapeutically effective amount of indomethacin administered by way of said medicaments. |
申请公布号 |
US9089471(B2) |
申请公布日期 |
2015.07.28 |
申请号 |
US201414284981 |
申请日期 |
2014.05.22 |
申请人 |
iCeutica Pty Ltd. |
发明人 |
Dodd Aaron;Meiser Felix;Norret Marck;Russell Adrian;Bosch H. William |
分类号 |
A61J3/02;A61K31/405;A61K9/14;A61K9/51;B82Y5/00 |
主分类号 |
A61J3/02 |
代理机构 |
Fish & Richardson P.C. |
代理人 |
Fish & Richardson P.C. |
主权项 |
1. A method of treating pain comprising administering a solid unit dose of a pharmaceutical composition containing 20 mg of indomethacin wherein the unit dose when tested in vitro by USP Apparatus I (Basket) method of U.S. Pharmacopoeia at 100 rpm at 37° C. in 900 ml of 100 mM citric acid buffer (pH 5.5±0.05) has a dissolution rate of indomethacin such that at least 83%, by weight, is released by 75 minutes and wherein the D90 of the indomethacin, on a particle volume basis, is selected from the group consisting of: less than 5000 nm, less than 4000 nm, 3000 nm, less than 2000 nm, less than 1900 nm, less than 1800 nm, and less than 1700 nm. |
地址 |
Philadelphia PA US |